If you have heartburn, you may use an H2 blocker (H2 receptor antagonist) to make your stomach acid less acidic and less irritating to your esophagus. If you take aspirin for heart disease, you might benefit from an H2 blocker, as well. Because aspirin tends to remain in the stomach, it has the potential to cause gastrointestinal bleeding and ulcers when taken more than four times per week or in high doses. In an effort to dissolve the aspirin, the stomach secretes more acid, which can burn a hole in the stomachs lining. By lowering acidity, H2 blockers can help prevent this from happening.