Most heart attacks occur when fatty plaques in the arteries rupture, spilling their contents into the bloodstream. This process, which is caused by inflammation, triggers the release of an enzyme called lipoprotein-associated phospholipase A2 , or Lp-PLA2. The higher the level of Lp-PLA2 in the blood, the greater the risk of stroke, first or recurrent heart attack or poor outcome after a heart attack. It can also predict increased risk of cardiovascular disease in people with insulin sensitivity/pre-diabetes is part of metabolic syndrome, but theyre not synonymous.
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