The Breakdown of Niacin May Cause Heart Attack, Stroke

Researchers find high blood levels of 4PY, a breakdown metabolite of niacin, are associated with double the risk of a cardiovascular event.


More than 50 years ago, niacin was among the first drugs used to lower cholesterol in hopes of preventing heart attack and stroke. Now, in an ironic turn of events, a team working with Stanley Hazen, MD, PhD, Chair of Cardiovascular & Metabolic Sciences at Cleveland Clinic’s Lerner Research Institute, discovered thata substance produced during the breakdown of niacin, 4PY, causes vascular inflammation, a contributor to heart disease.

To continue reading this article or issue you must be a paid subscriber. Sign in

Subscribe to Heart Advisor

Get the next year of Heart Advisor for just $20. And access all of our online content - over 2,000 articles - free of charge.
Subscribe today and save 38%. It's like getting 5 months FREE!
Already Subscribed?
Click Here to Sign In | Forgot your password? | Activate Web Access