If you have heart failure, your heart is not functioning as well as it should. You will need to work closely with your doctor to prevent the condition from getting worse. How successful you will be may depend on the type of heart failure you have. While there are many effective medications for treating heart failure with reduced ejection fraction (HFrEF), most simply don’t work in patients with heart failure with preserved ejection fraction (HFpEF). Nor has there been an effective treatment for heart failure that occurs when the heart muscle is infiltrated by amyloid protein. Outcomes for these patients have been poor.