Centrally active ACE inhibitors such as captropil (Capoten) and fosinopril (Monopril), used to treat hypertension and congestive heart failure, are associated with slower rates of cognitive decline among the elderly compared to other blood pressure medications such as benazepril (Lotensin) and enalapril (Vasotec), according to research presented at the May conference of the American Geriatrics Society. Because centrally active ACE inhibitors cross the blood-brain barrier, the membrane that protects the brain from chemicals in the blood, it is thought that they help fight dementia by reducing inflammation in the brain and decreasing oxidative stress, which is cell death caused by free radicals in the body
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