Heart Beat: February 2019

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Obese individuals tend to have other risk factors for heart attack and stroke, such as diabetes, high blood pressure and high cholesterol levels. That has caused the role of obesity as a cardiovascular risk factor to be questioned. A study spearheaded at Cleveland Clinic suggests that it is. The authors conducted a meta-analysis of five studies with a total of 900,000 participants in which a genetic polymorphism associated with obesity was used to determine its potential link to cardiovascular outcomes. They found that as body-mass index rose above the mean, risk of type 2 diabetes and coronary artery disease (CAD) rose with it. No connection between obesity and stroke was seen. Although these results do not prove that obesity causes diabetes and CAD, they strongly suggest that obesity increases the risk these issues will develop (JAMA Network Open, November 2018).
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