Doctors often enroll multiple medications to fight a killer.

A reader in Pennsylvania tells us he’s “wrapped around the axle” with questions about blood pressure medications. How do doctors decide when and what to prescribe? How do the different drugs work? What are the side effects? What’s best for which patients?

In the spirit of the season, we asked Donald G. Vidt, M.D., an expert on high blood pressure at The Cleveland Clinic, to do some unwrapping. Here’s a medical insider’s look at medications that offer proven protection against heart attack and stroke. …

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